Volume 2, Issue 3, June 2021, Pages 52 - 57
PVP-Induced Synthesis of Silica Nanoparticles with Tailored Size for pH-Controlled Drug Release
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Authors
Wei Yang1, Zheng Yang2, *
1
Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China
2
School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, P. R. China
*
Corresponding author. Email: zhengyang@fynu.edu.cn
Corresponding Author
Zheng Yang
Article History
Received 8 December 2020Accepted 9 April 2021
Available Online 21 April 2021
- DOI
- https://doi.org/10.2991/mathi.k.210414.001
- Keywords
- PVP-induced synthesis
SiO2 nanoparticles
drug delivery
pH-controlled drug release
cancer treatment - Abstract
Traditional cancer therapy faces the main fail due to the effect of drug burst release, hindering the long-term therapeutic efficacy. SiO2 nano systems possess high-capacity and pH-controlled release for anti-cancer drug, improving the curative efficacy in cancer treatment. Thus, we designed a novel method to construct Silica Nanoparticles (SiO2 NPs) with diameters of ca. 150 nm by adding different amounts of PVP. The maximum drug-loading of the synthesized SiO2 NPs is about 30 μg·mg−1, exhibiting excellent pH-responsive drug releasing ability in the simulated physiological environment. Meanwhile, the prepared SiO2 NPs also harbor well biocompatibility, which are suitable for potential cancer therapy in clinic.
- Copyright
- © 2021 The Authors. Published by Atlantis Press B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite This Article
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TY - JOUR AU - Wei Yang AU - Zheng Yang PY - 2021 DA - 2021/04/21 TI - PVP-Induced Synthesis of Silica Nanoparticles with Tailored Size for pH-Controlled Drug Release JO - Materials Highlights SP - 52 EP - 57 VL - 2 IS - 3 SN - 2666-4933 UR - https://doi.org/10.2991/mathi.k.210414.001 DO - https://doi.org/10.2991/mathi.k.210414.001 ID - Yang2021 ER -
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